Molecular Docking Studies and Insilico ADMET Screening of Some Novel Chalcone Substituted 9-Anilinoacridines as Topoisomerase II Inhibitors

9-anilinoacridine derivatives are inhibiting DNA topoisomerase II (topoII) due to the ability of acridine nucleus to intercalate into DNA base pair. In this study, the identification of potential ligands from chalcone substituted 9-anilinoacridines targeted against topoisomerase-II (1ZXM) by molecular modelling and docking studies using Schrodinger suit-2013 Maestro 9.3 version. Insilco ADMET screening also performed by