A Novel Development of Cyclic Tetrapeptide as an EGFR Tyrosine Kinase Inhibitor Assayed by ELISA Experiment and Docking Study
Abstract
The first purpose of this project is to synthesize innovative cyclic peptides and test them as Epidermal Growth Factor Tyrosine Kinase Inhibitor (EGFR-TKI) by Enzyme-Linked Immuno Sorbent Assay (ELISA) experiment. The Cyclic Phe-Phe-Phe-Gly Tetrapeptide (CPTP) exhibited a strong IC50 of 55.6 nM while cyclic heptapeptides, μM level. The second purpose is to compare
Article Information
| Journal | SF Journal of Pharmaceutical and Analytical Chemistry |
| Article Type | Research Article |
| Volume | 3 |
| Issue | 1 |