Lung Aging Related to Oxidative Stress and Mitochondrial Biogenesis in COPD Patients

Aims: To identify the physiological and pathological (COPD) non-respiratory lung aging by determining gene expression changes in the airways of genes encoding antioxidants and of mitochondrial biogenesis' markers. Methods: Three groups were recruited: group I (7 healthy-young-controls, mean age=36.8 years), group II (10 healthy-elderly, mean age=68.7 years) and group III (10 elderly-COPD, mean age=68.7