Pancreatic Neuroendocrine Tumor with Intraductal Growth

Pancreatic neuroendocrine tumors (PanNETs) rarely involve the main pancreatic duct. We report a case of 79-year-old-man, diagnosed with an incidental pancreatic cystic tumor. Abdominal CT scan and MRI were compatible with Main Duct Intraductal Papillary Mucinous Neoplasms (MDIPMN) with “high-risk stigmata” of malignancy. Pancreaticoduodenectomy was performed. Intraoperative histological analysis showed a PanNET instead of an MD-IPMN. We review the literature and discuss this unusual presentation of PanNETs.