Research Article
Article 1001
Authors:
Ahmed RM<sup>1*</sup>, Ibrahim A<sup>2</sup>, El-Gendy AE<sup>1</sup> and Hadad GM<sup>3</sup>
Abstract:
This article aims to explain the steps for application of quality by design (QbD) concept to analytical method development and validation, by using an example of simultaneous determination of four antidiabetic drugs (Metformin HCl, Vildagliptin, Sitagliptin phosphate mono hydrate and Pioglitazone HCl) in its pharmaceutical dosage form by RP-HPLC. By using QbD tools, enable earlier understanding and identification of variables
Research Article
Article 1002
Authors:
Al-qadasy MKO<sup>1</sup>, Babaqi AS<sup>1</sup>, Al-Abyadh MM<sup>2*</sup> and Al-kaf AG<sup>3</sup>
Abstract:
This study investigate concentrations of heavy metals (Pb, Cd, Hg and As) in water and muscle fish,collected from three different sites (Aden, Al-Hodeidah and AL-Mukalla) of the Red Sea and the Gulf of Aden in Yemen’s coastal. Fresh samples were purchased from near the sea public auction site locations. The four species of fish (emperor) Lethrinus mahsena, (Longtail tuna)
Research Article
Article 1003
Authors:
Yan Yi<sup>1</sup>, Ying Wang<sup>2</sup>, Song-Lin Li<sup>3</sup>, Wen-Cai Ye<sup>2</sup> and Qing-Wen Zhang<sup>1*</sup>
Abstract:
Bawanghua, the flower of Hylocereus undatus, is an edible herb. Quercetin, kaempferol and isorhamnetin glycosides are the major components in Bawanghua. The major flavonoid glycosides in Bawanghua are too identical to be separated in preparative scale which hindered the using of those glycosides as references in routine quality control method. Quantification of the flavonoid aglycones hydrolyzed from their glycosides
Research Article
Article 1004
Authors:
Kalirajan R<sup>*</sup>, Pandiselvi M, Sankar S and Gowramma B
Abstract:
9-anilinoacridine derivatives are inhibiting DNA topoisomerase II (topoII) due to the ability of acridine nucleus to intercalate into DNA base pair. In this study, the identification of potential ligands from chalcone substituted 9-anilinoacridines targeted against topoisomerase-II (1ZXM) by molecular modelling and docking studies using Schrodinger suit-2013 Maestro 9.3 version. Insilco ADMET screening also performed by
Mini Review
Article 1005
Authors:
Sahu JK<sup>1*</sup> and Mishra A<sup>2</sup>
Abstract:
Multiple sclerosis (MS) is known as chronic autoimmune, inflammatory neurological disorder of the central nervous system which may cause progressive walking impairment which results to disability, loss of independence and diminished quality of life. Dalfampridine (4-aminopyridine), a voltagedependent potassium channel blocker, has been shown to improve walking in patients with MS, as demonstrated by an increase
Mini Review
Article 1006
Authors:
Loh YC<sup>1*</sup>, Tan CS<sup>1</sup> and Omar WMW<sup>2*</sup>
Abstract:
The present review aims to suggest an alternative approach to pharmacological research. That is,the use of traditional Chinese medicine, which could potentially solves the major problems faced by global scientists in recent years especially to overcome the relatively low
Research Article
Article 1007
Authors:
Zeng W<sup>*</sup>, Xu Y, Constanzer ML, Goykhman D and Woolf EJ
Abstract:
A simple LC-MS/MS method for the quantification of sugammadex in human plasma is described. Samples were prepared using protein precipitation with acetonitrile containing 0.37% hydrochloric acid as precipitator and Waters Ostra plate for protein and phospholipid removal.
Review Article
Article 1008
Authors:
Kapoor Y<sup>1</sup>, Dubey S<sup>1</sup>, Kar S<sup>2</sup> and Kumar K<sup>1*</sup>
Abstract:
Cancer is always being a matter of concern and when it comes to its treatment Chimeric antigen receptor (CAR) T cell therapy is an approaching and is found to be a promising cancer treatment. In this review, we focus on the production and design of CAR T cell
Research Article
Article 1009
Authors:
Khandare PM, Ingle RD, Tekale SU, Jadhav AS, Mashele S, Kendrekar PS<sup>*</sup> and Pawar RP<sup>*</sup>
Abstract:
A simple and green one pot protocol for the synthesis of bioactive pyran annulated heterocyclic compounds at room temperature in ethanol has been developed using lemon peel powder as a catalyst.
Research Article
Article 1010
Authors:
Ochoa-Andrade AT<sup>*</sup>, Fierro MV, Bauzán ML, Origoni MX and Trezza VM
Abstract:
The aim of the present work was to study the hydrogel-forming polysaccharides carrageenan, guar and xanthan gum as potential absorbents in moisture activated dry granulation (MADG). Preferences of formulators regarding absorbents tend to incline towards microcrystalline cellulose
Research Article
Article 1011
Authors:
Al-Okab RA<sup>*</sup>, Abdul Galil MS and Amanyabdouh
Abstract:
Replacement of toxic reagents was established to attain the standards of clean chemistry. Novel green reagent for simple and highly sensitive spectrophotometric determination of trace amounts of
